Abstract: This paper is based on the analysis and research on the silver-lead-zinc polymetallic ore in New Ballyhoo Banner in southern Manzhouli of Inner Mongolia. Because metal mineralization brings rock formations，the geophysical features such as low resistivity, high polarization rate and uneven distribution of magnetization, the comprehensive geophysical methods are adopted including high-precision magnetic measurement, high-power induced polarization, IP field middle gradient and controlled source audio-frequency magnetotellurics. In the survey work of multi-metal ore deposits, from surface sweeping to single point measurement, and from single point to section going deeper layer by layer, the resolution of measurement is continuously improved, and various geophysical methods support and complement each other, so explorers can successfully predict the direction, scale and volume of the metallogenic belts in conjunction with geochemical exploration, geological survey and drilling. It has provided a strong basis for completing the exploration task of predicting the reserve volume of ore bodies. The research conclusions of this exploration case have thus a high reference value in the same type of exploration work.